Leucocyte adhesion deficiency presenting as a chronic ileocolitis.

Leukocyte Adhesion Deficiency Type 1 Presenting as Leukemoid Reaction

The hallmarks of leukocyte adhesion deficiency (LAD) are defects in the leukocyte adhesion process, marked leukocytosis and recurrent infections. These molecular and clinical manifestations result from an impaired step in the inflammatory process, namely, the emigration of leukocytes from the blood vessels to sites of infection, which requires adhesion of leukocytes to the endothelium. Over las...

Periodontal Involvement in Leukocyte Adhesion Deficiency: Review of the Literature and a Case Report

Objective: Leukocyte adhesion deficiency(LAD) is a scarce, autosomal recessive inherited disorder . LAD-I which is the most common type occurs due to mutations on the CD18 gene. This mutation leads to absence or severe reduction of leukocyte cell surface expression of ß2 integrin molecules which are necessary for the adhesion of the leukocytes to the endothelial cells, transendothelial mi...

Non-Hodgkin's lymphoma in a patient with leucocyte adhesion deficiency.

Zinc deficiency and photoreceptor dysfunction in chronic liver disease.

1. In nine patients with chronic liver disease photoreceptor function was tested, by measurement of the B-wave amplitude of dark adaptation by electroretinography, and the leucocyte content and plasma concentration of zinc were determined. 2. Four of the patients were leucocyte zinc-depleted and had impaired photoreceptor function, but this was normal in the five with normal leucocyte zinc cont...

Recurrent pyoderma gangrenosum and cystic acne associated with leucocyte adhesion deficiency due to novel mutations in ITGB2: successful treatment with infliximab and adalimumab.